You did not specify which platform you’re patching.
As trn points out, depends on your environment.
This isn’t something we, or even IBM, can tell you. You need to make an informed decision based on the information available from the vendor of the updates, not the tool you use to deploy said updates.
A quick google search returns several Microsoft pages detailing best practices for Microsoft updates. I’m sure the same is true for Red Hat, or CentOS, or IBM Linux, or whatever OS you’re planning on patching.