KB3055014 (MS15-080) requires Lync 2013 (Skype for Business) users to install KB2889853, KB3054853, and KB2817427

Users of Lync 2013 (Skype for Business) must first install the following KBs before installing KB3055014 to avoid encountering issues with Lync.

For more information about installing KB3055014, see the Prerequisites section in https://support.microsoft.com/en-us/kb/3055014.

Application Engineering Team
BigFix Patch for Windows

Are these dependencies handled in the relevance, or is this something that has to be handled manually?

Hi jgstew. These have to be handled manually.