This turned out to be a corrupt database record relating to an attempt to run the software distribution wizard on a large file (>5GB). It prevented consoles from launching and web reports from running.
Fortunately L3 provided SQL to identify the corrupt data. After it was deleted, normal operations have resumed.
I attempted to reproduce issue, but was unable. I successfully used the wizard on the same 5.2GB file that my console operator attempted yesterday. For some unknown reason, it failed for the console operator in such a way as to create a corrupt database value for it. Then when web reports attempted to run or folks tried to open their console, it would literally fail. I’ve been using Bigfix for over a decade since version 4 and have never seen that happen before. Strange.