You can configure BigFix to ignore the “PendingFileRenameOperations” registry key, where we usually check to see whether a restart is needed. See Stuck in Pending Restart status even after reboot
Of course, by ignoring the key, you could miss cases where a second restart actually is needed by the series of patches you installed. Where systems are misusing the PendingFileRenameOperations entries, it can be difficult to tell whether are restart is actually still needed.