I would like to find out which options are available for me configure certain individual groups/computers from receiving patches from patch management.
Is there a setting that can do this?
You could adjust the Relevance for the Patch sites to exclude the desired systems.
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There are many different ways to do this.
You can create an automatic group for all computers that should get patches and target that group when deploying the patches.
You could also use the automatic group to adjust the site subscriptions like @TimRice suggests, or you could use the same relevance in the site subscriptions as the automatic group.
I definitely recommend using automatic groups to aid in targeting machines during deployment in general.
If you want to dynamically move machines into and out of sites, you can use relevance that examines a custom client setting. Then you can use a Task to set the setting to the desired state.
Exists setting "CustomSettingName" whose ((exists value of it) and (value of it = "SomeValue")) of client