There isn’t really a “one size fits all” recommendation here (even given different environment sizes). The recommendations to fine tune these settings (as is the case with many really), will vary between environments, and really depends on conditions and requirements.
Are there specific scenarios you are concerned about and/or issues you are trying to resolve?
Thanks for the reply @Aram but I am able to understand only 1 setting which is _BESRelay_HTTPServer_MaxConnections apart from it _BESRelay_HTTPServer_RequireTLS12 have no info your provided link & for setting BESRelay_Downloads_OlderThanInDays provided description is very small & not helpful so if you can provide some more insight/clarity on these two relay settings.
And what could be available settings to achieve below things (In Ref to Relay fine tuning only)-