Registry Modification don't work

I believe the challenge you are facing here has to do with the fact that you are trying to modify keys under HKEY_CURRENT_USER. Since the BigFix Client process runs as Local SYSTEM, the user context is different.

Please see the following technote for some information and suggestions on how to approach this:
http://www-01.ibm.com/support/docview.wss?uid=swg21505908

There are a lot of other posts on the forum related to this that might help to explore as well, such as: