Jason,
The “wwwrootfolder” value of key “HKLM\SOFTWARE\BigFix\Enterprise Server” does not exist in OS registry, I was able to find it under “HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\BigFix\Enterprise Server” with different path for wwwrootfolder between the new installation and previous installation.
I’ve opened a support case for this issue, and it looks like they pointed me to : Relocation of wwwrootbes directory to another partition
Regards,
SS