I would avoid using the “descendants of” inspector for searching files across entire drives in a property as it will most likely have very undesirable side effects on the client (timeouts and/or client busy for long periods of time so unable to process other property and fixlet evaluation as well as file errors). The approach I’ve used that can avoid such issues I described in your post Required Analyses Fixlet to identify a file existance in entire system with the file location. I’ve used this for a number of file searches across over 100k managed endpoints with great success.
Regs
Rob