Add the IEM relay and clients machine to a new AD server

I build up a new AD server, if I add the IEM relay and clients machine to the new AD domain, will there be a problem?

There shouldn’t be, unless you have lots of open actions, relevance, and automation tied to AD membership and AD groups… and even then it is more likely that things would just not happen, instead of things happening that should not.

Basically BigFix/IEM has nothing to do with AD at all, except that it is aware of it.