Yes, with relevance, you can basically define any criteria you want, including creating windows of time for things to run within.
Is this for servers, workstations, or both?
See this related example: https://bigfix.me/relevance/details/3003590
See this related post: Can An Action Be Scheduled Every 2 Weeks (Not 15 days)?
This is how you would cause something to only run on Wednesdays or Fridays:
exists (it as string) whose(it = "Friday" OR it = "Wednesday") of current day_of_week
https://bigfix.me/relevance/details/3003635
I would recommend using a different relevance statement to determine the number of the week.